Recombinant Human B-lymphocyte antigen CD19(CD19),partial (Active)

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Code CSB-AP005061HU
Product Type CD Antigen
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Uniprot No. P15391
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Storage Buffer Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, 0.05% NaN3, pH 7.4
Alias B-Lymphocyte Antigen CD19; B-Lymphocyte Surface Antigen B4; Differentiation Antigen CD19; T-Cell Surface Antigen Leu-12; CD19
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined by its ability to binding CD19 used funtional ELISA is less than 20 ug/ml
Purity Greater than 80% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence PEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWK
Research Area Immunology
Source Mammalian cell
Gene Names CD19
Expression Region 20-291aa
Tag Info C-terminal FC-tagged
Mol. Weight 57.3 kDa
Protein Description Extracellular Domain
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Function Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Involvement in disease Immunodeficiency, common variable, 3 (CVID3)
Subcellular Location Membrane, Single-pass type I membrane protein
Database Links

HGNC: 1633

OMIM: 107265

KEGG: hsa:930

STRING: 9606.ENSP00000437940

UniGene: Hs.652262

Pathway PI3K-Akt signaling pathway
B cell receptor signaling pathway
Hematopoietic cell lineage

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