Recombinant Human Leptin protein(LEP) (Active)

In Stock

Code CSB-AP000061HU
Product Type Hormone
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P41159
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias Obese protein
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human Leptin R transfected BaF3 murine proB cells is less than 2 ng/ml, corresponding to a specific activity of >5.0x105 IU/mg.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence VPIQKVQDDT KTLIKTIVTR INDISHTQSV SSKQKVTGLD FIPGLHPILT LSKMDQTLAV YQQILTSMPS RNVIQISNDL ENLRDLLHVL AFSKSCHLPW ASGLETLDSL GGVLEASGYS TEVVALSRLQ GSLQDMLWQL DLSPGC
Research Area Signal Transduction
Source E.coli
Gene Names LEP
Expression Region 22-167aa
Tag Info Tag-Free
Mol. Weight 16.0 kDa
Protein Description Full Length of Mature Protein
PubMed ID 7984236; 7789654; 8626726; 7499240; 8621021; 15489334; 10428856; 9166907; 9144295; 9500540
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Function Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways
Involvement in disease Leptin deficiency (LEPD)
Subcellular Location Secreted
Protein Families Leptin family
Tissue Specificity Adipose tissue is the main source of leptin it is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary
Database Links

HGNC: 6553

OMIM: 164160

KEGG: hsa:3952

STRING: 9606.ENSP00000312652

UniGene: Hs.194236

Pathway Jak-STAT signaling pathway
Adipocytokine signaling pathway
AMPK signaling

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