Recombinant Human CD40 ligand(CD40LG),partial

In Stock
Code CSB-AP005191HU
Product Type Immune Checkpoint
Size US$65
Uniprot No. P29965
Lead Time 5-10 business days
Storage Buffer Lyophilized from a 0.2 μm filtered 20 mM PB, 200 mM NaCl, 0.1 mM EDTA, pH 7.0
Alias CD40 Ligand; CD40-L; T-Cell Antigen Gp39; TNF-Related Activation Protein; TRAP; Tumor Necrosis Factor Ligand Superfamily Member 5; CD154; CD40LG; CD40L; TNFSF5; TRAP
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined by the dose-dependent stimulation of IL-12 & IL-8 induction by PMB cells is less than 20 ug/ml.
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence MQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL
Research Area Immunology
Source E.coli
Gene Names CD40LG
Expression Region 113-261aa
Tag Info Tag-Free
Mol. Weight 16.2 kDa
Protein Description Partial
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Function Cytokine that binds to CD40/TNFRSF5
Involvement in disease Immunodeficiency with hyper-IgM, type 1 (HIGM1)
Subcellular Location Cell membrane, Single-pass type II membrane protein, Cell surface, SUBCELLULAR LOCATION: CD40 ligand, soluble form: Secreted
Protein Families Tumor necrosis factor family
Tissue Specificity Specifically expressed on activated CD4+ T-lymphocytes.
Database Links

HGNC: 11935

OMIM: 300386

KEGG: hsa:959

STRING: 9606.ENSP00000359663

UniGene: Hs.592244

Pathway NF-kappa B signaling pathway
T cell receptor signaling pathway

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