CD9 Monoclonal Antibody

1. assays. Results from the present study demonstrated that CD9 was highly expressed in the highly metastatic Hepatocellular carcinoma (HCC)cells and promoted HCC cell migration. This protein may be a novel target for regulating the invasive phenotype in HCC. PMID: 29749468
2. The species-specific traits in CD9 and CD81 distribution during sperm maturation were compared between mice and humans. A mutual position of CD9/CD81 is shown in human spermatozoa in the acrosomal cap, however in mice, CD9 and CD81 occupy a distinct area. PMID: 29671763
3. CD9 expression predicts some clinical characteristics and indicates an unfavorable prognosis in acute lymphoblastic leukemia patients. PMID: 29286918
4. CD9-CD81 blockage reduces exosome-mediated HIV-1 entry. PMID: 29429034
5. Exosomal markers CD63 and CD9 are elevated in pancreatic tumor tissues. PMID: 28609367
6. CD9 expression could be a biomarker for poor prognosis in invasive breast carcinoma PMID: 28178752
7. CD9 stabilizes gp130 by blocking its ubiquitin-dependent lysosomal degradation to promote the IL6-gp130-bone marrow X-linked non-receptor tyrosine kinase-STAT3 signaling for maintaining GSC selfrenewal and tumorigenic capacity. PMID: 27740621
8. CD9 was highly expressed on extravillous trophoblast (EVT) at the boundary region of EVT invasion and intravascular EVT. CD9 expression on Swan71 cells was reduced under hypoxic conditions, while its expression was increased by co-culture with HUVEC. CD9 could attenuate EVT invasion under the influence of an oxygen environment and maternal endothelial cells, proposing CD9 as a potential regulator of human placentation. PMID: 27780531
9. As for 18Lin(-), CD34(-) HSCs are characterized by low expression of the tetraspanin CD9, which promotes homing, and high expression of the peptidase CD26, which inhibits homing. PMID: 28687990
10. The findings suggest that, in contrast with previous models, the ligand-binding site of integrin alphaVbeta3, binds to the constant region (helices A and B) of the EC2 domain of CD9, CD81, and CD151 antigens. PMID: 27993971
11. Data suggest that CD9 should be further evaluated as a target for glioblastoma treatment. PMID: 26573230
12. Collectively, using tetraspanin CD9 in tandem with E-cadherin as a biomarker in renal cell carcinoma will help to not only distinguish between types, but also predict the metastatic potential of RCC. PMID: 26855131
13. Data indicate that CD9 is implicated in BCC invasiveness and metastases by cellular mechanisms that involve specific CD9+ plasma membrane protrusions of BCCs. PMID: 25762645
14. CD9-enriched microdomains negatively regulate LPS-induced receptor formation by preventing CD14 from accumulating into lipid rafts. [Review] PMID: 26378766
15. Results indicate that CD9 downregulation promoted pancreatic cancer cell proliferation and migration through at least in part, enhancing the cell surface expression of EGFR. PMID: 25955689
16. CD9 expression is upregulated and its expression is correlated with tumor stage and lymph node metastasis in esophageal squamous cell carcinoma patients PMID: 26045817
17. Although the current findings did not prove any hypothesis, the indispensable role of CD9 in fertilization process was not excluded and the precise role of CD9 remains unexplained. [review] PMID: 25536312
18. CD9 plays a role in the dysmegakaryopoiesis that occurs in primary myelofibrosis. PMID: 25840601
19. High CD9 is associated with B acute lymphoblastic leukemia. PMID: 26320102
20. These results suggested that the mechanism underlying CD9-induced suppression of cell proliferation may involve the inhibition of phosphorylation of EGFR and the activity of PI3K/Akt and MAPK/Erk signaling pathways PMID: 25760022
21. OY-TES-1 downregulation in liver cancer cells inhibits cell proliferation by upregulating CD and downregulating NANOG. PMID: 25673160
22. Low levels of CD9 coincidental with a novel nonsense mutation in glycoprotein Ibbeta in a patient with Bernard-Soulier syndrome. PMID: 26275786
23. The cysteine residues involved in the formation of the disulfide bridges in CD9 EC2 were all essential for inhibiting multinucleated giant cell formation but a conserved glycine residue in the tetraspanin-defining 'CCG' motif was not. PMID: 25551757
24. alteration in CD9 expression was sufficient to profoundly disrupt cellular actin arrangement and endogenous cell contraction by interfering with RhoA signaling. PMID: 25184334
25. The mechanism responsible for this negative regulation exerted by CD9 on LFA-1 adhesion does not involve changes in the affinity state of this integrin but seems to be related to alterations in its state of aggregation. PMID: 26003300
26. The results demonstrate that hypoxia regulates CD9 expression and CD9-mediated keratinocyte migration via the p38/MAPK pathway. PMID: 25200404
27. Report shows that breast cancer cells contain a nuclear CD9 pool and that the abrogation of CD9 expression results in multipolar mitoses and polynucleation. PMID: 25103498
28. this study indicated that sialylation involved in the development of MDR of AML cells probably through ST3GAL5 or ST8SIA4 regulating the activity of PI3K/Akt signaling and the expression of P-gp and MRP1. PMID: 24531716
29. switch from alphavbeta5 to alphavbeta6 integrin plays a key role in CD9-regulated cell migration and MMP-9 activation in keratinocytes PMID: 25265322
30. High expression of CD9 was statistically associated with older patients PMID: 24553302
31. CD9 and CD63 tetraspanins block HIV-1-induced cell-cell fusion at the transition from hemifusion to pore opening. PMID: 24608085
32. Loss of CD9 expression is associated with enhancement of invasive potential of malignant mesothelioma. PMID: 24466195
33. CD9 and CD151 support integrin-mediated signaling at the immunological synapse. PMID: 24723389
34. Introduction of CD9 expression in Raji cells resulted in significantly increased cell proliferation and HDAC activity compared to mock transfected Raji cells. PMID: 24747564
35. Heparin-binding epidermal growth factor and CD9 are likely implicated in processes that are highly relevant for MS lesion formation PMID: 24038577
36. this study points to EGFR as a key mediator between CD9-mediated pro-MMP-9 release and cellular invasion of HT1080 cells. PMID: 24246676
37. The second extracellular loop of CD9 was responsible for the upregulation of MMP-9 production. PMID: 23840773
38. This is the first study of the expression and prognostic potential of the tetraspanins in oral dysplasia. PMID: 24201754
39. Low CD9 expression is associated with malignant mesothelioma. PMID: 23128478
40. Both CD9/CD81-silenced cells and CD151-silenced cells showed delayed alpha3beta1-dependent cell spreading on laminin-332. PMID: 23613949
41. Data indicate that CD9 acts as scaffold and assembles a ternary JAM-A-CD9-alphavbeta3 integrin complex from which JAM-A is released upon bFGF stimulation. PMID: 23389628
42. these data suggest that CD9 is a novel marker for a human germinal center-B cell subset that is committed to plasma cell lineage. PMID: 23291167
43. CD9 overexpression was confirmed in osteotropic cells. CD9 was significantly overexpressed in bone metastases versus primary tumors and visceral metastatic lesions. PMID: 23225418
44. tetraspanin CD9 modulates molecular organization of integrins in lymphatic endothelial cells, thereby supporting several functions required for lymphangiogenesis PMID: 23223239
45. Low CD9 expression is associated with gallbladder neoplasms PMID: 22613496
46. identifies human male germ cells with capability of long-term survival and cell turnover in the xenogeneic testis environment PMID: 22592495
47. Knockdown of CD9 by siRNA and blockage of CD9 activity by ALB6 in ovarian cancer cells demonstrated that constitutive activation of NF-kappaB is CD9 dependent and that CD9 is involved in anti-apoptosis PMID: 22095071
48. CD9 increases GCM1 expression via the cAMP/PKA signaling pathway, resulting in the increase in ERVWE1 expression. PMID: 19692500
49. The absence or down-regulation of CD9 expression and point mutation may play a considerable role in the pathway of the malignant transformation in the BEAS-2B cells induced by mineral powder. PMID: 17997888
50. CD9 associates with ADAM17 and, through this interaction, negatively regulates the sheddase activity of ADAM17. PMID: 21365281
51. decreased levels of CD9 are strongly associated with an increased risk of recurrence. PMID: 21521534
52. Expression of CD9 increased in glottic carcinoma and adjacent tissues. PMID: 20422979
53. show for the first time that CD9 and CD81 act as molecular partners of trimeric FcvarepsilonRI on human antigen-presenting cell PMID: 21241315
54. CD9 links to several signaling pathways and epigenetic modification for regulating the cancer stem cell properties of B-ALL. PMID: 21549094
55. Functional and biochemical studies of CD9 in fibrosarcoma cell line. PMID: 21161334
56. CD9-deficiency leads to impaired localization of talin1 to focal adhesions and correlates with increased motility of breast cancer cells. PMID: 21428940
57. Low CD9 is associated with metastatic gastrointestinal stromal tumors. PMID: 21244575
58. CD9 expression was modulated via CXCR4, G-protein, protein kinase C, phospholipase C, extracellular signal-regulated kinase, and Janus kinase 2 signals in cord blood CD34+ hematopoietic stem cells PMID: 21063023
59. CD9 expression in gastric cancer appears to be associated with poor prognosis. PMID: 20547009
60. These findings imply that CD9 is inversely correlated with B lymphoma progression, and CD9 inactivation may play an important role in B lymphoma transformation. PMID: 20566742
61. Findings implicate CD9 in the cell adhesion-mediated drug resistance mechanisms in small cell lung cancer. PMID: 20940407
62. These observations provide an example for a posttranscriptional fine-tuning of CD9 gene expression in tumor cells. PMID: 20118909
63. CD10 and CD9 expression correlates with the invasiveness and metastatic potential of malignant melanoma. PMID: 17845760
64. CUGBP1 directly controls CD9 expression. PMID: 20227387
65. Data show that overexpression of CD9 in the metastatic melanoma cell line WM9 decreased anchorage-independent growth, while transient overexpression of CD9 in the radial growth phase cell line SbCl2 resulted in the gain of Matrigel invasion activity. PMID: 19777564
66. peripheral blood monocytes treated for 5--8 days with GM-CSF (i.e. mature Mphi) acquired the capacity to assemble CD9 with alpha3-beta1 integrin, tyrosine phosphatase SHP-1 and with CD46. PMID: 11858824
67. CD9 protein expression was inversely associated with lymph node metastasis. PMID: 11920609
68. By site-directed mutagenesis, CD9 was found to be palmitoylated at any of the four internal juxtamembrane regions. PMID: 11959120
69. C-kit is physically associated with transmembrane 4 superfamily proteins CD9, CD63, and CD81, that may negatively modulate c-kit and thus regulate c-kit receptor sensitivity to SLF in hematopoietic progenitors. PMID: 12036870
70. Infertility of CD9-deficient mouse eggs is reversed by human CD9 PMID: 12086470
71. Data show that the expression of the PAINS-13 epitope depends on CD9 association with alpha(6)beta(1) integrin. PMID: 12411441
72. The second extracellular loop sequence (173)LETFTVKSCPDAIKEVFDNK(192) is largely responsible for trasnfected human CD9-mediated CHO cell adhesion to fibronectin and fibronectin pericellular matrix assembly. PMID: 12453879
73. low expression of CD9 may contribute to the highly invasive and metastatic phenotype of small cell lung cancer PMID: 12569360
74. downregulation of CD9 antigen is associated with breast tumor progression PMID: 12579280
75. CD9 expression was rather intensified in gastric cancer tissue in comparison with normal tissues. CD9 expression was more prominent in advanced gastric cancer. PMID: 15047125
76. CD9 does not have a role in progression of human osteosarcoma or predict its prognosis PMID: 15145525
77. CD9 activates the p46 Shc isoform in tumor cells and leads to apoptosis PMID: 15226408
78. cell-surface expression of CD9, a beta1 integrin-associated transmembrane protein that is involved in cell adhesion and cell motility events, was enhanced in the ra-a47 anti-sense oligonucleotide-treated cells. PMID: 15389525
79. The MRP-1/CD9 gene expression was down-regulated in gastric cancer, its expression was probably related to the carcinogenesis and histology types of gastric cancer. PMID: 15476162
80. endothelial CD9 tetraspanins relocalize to the contact site with transmigrating leukocytes and associate laterally with both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) PMID: 15591117
81. leukocyte antigen-DR, CD38, and CD9 share a common pathway of tyrosine kinase activation in human monocytes PMID: 15941914
82. tetraspanin intra- and intermolecular interactions are mediated by conserved residues in adjacent, but distinct regions of TM1 and TM2 PMID: 15985154
83. phenotypic conversion and reversion of bladder cancer cells is controlled by a glycosynapse 3 microdomain through GM3-mediated interaction of alpha3beta1 integrin with CD9 PMID: 16103120
84. results have shown that CD-9 is present in prostate tumour epithelial cells and that it is regulated by androgens in LNCaP-FGC cells PMID: 16128989
85. CD9 is essential for the IL-16-mediated chemotaxis and activation, acting as an IL-16 receptor in HMC-1, a mast cell line that lacks CD4 PMID: 16144798
86. A role of CD9 in melanocyte motility was shown. PMID: 16297202
87. results suggest that the restored expression of CD9 in SCLC cells may reduce the metastatic spread of SCLC cells via the inhibition of cell proliferation and motility PMID: 16491954
88. EWI proteins EWI-2 and EWI-F, alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 organization PMID: 16537545
89. MRP-1/CD9 regulates the actin cytoskeleton by downregulating of the WAVE2, through the Wnt-independent signal pathway. PMID: 16682943
90. CD9 expression by multiple myeloma cells is upregulated in vivo by close interaction of the cells with endothelial cells and CD9 is involved in transendothelial invasion PMID: 16900214
91. CD9 molecules on endothelial cells participate in the mitogenic effect of platelets; results suggest that the tetraspanin CD9 plays an important role in endothelial regeneration PMID: 16951553
92. role of CD81 and CD9 on the cell-to-cell fusion process mediated by HIV-1, syncytia formation induced by HIV-1 envelope proteins and viral entry in human T lymphoblasts PMID: 17015697
93. Ectopic CD9 expression suppressed neurite-like process outgrowth & promoted apoptotic death of some SCLC cells. Its absence in SLCL may contribute to postadhesive morphologic differentiation, survival, & MMP-2 production via PI3K/Akt pathway. PMID: 17018612
94. results clearly point to an involvement of CD9 in the attachment, uptake or processing of adeno-associated virus-2 by target cells PMID: 17203208
95. Expression of CD9 in transitional cell carcinoma bladder is reported. PMID: 17393117
96. CD9 gene inactivation may play an important role in prostate cancer progression. PMID: 17406028
97. transferrin receptor and CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells PMID: 17407154
98. Data show that HIV-1 envelope glycoprotein (Env) and core protein (Gag) colocalize strongly with CD63 and CD81 and less strongly with CD9, and suggest that HIV-1 promotes virus assembly and cell-cell transfer by targeting these plasma membrane proteins. PMID: 17522207
99. establish for the first time a role for CD9 in the tumorigenic process PMID: 17582603
100. Nine potential tetraspanin CD9 partners, including claudin-1, were identified. PMID: 17644758

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HGNC: 1709

OMIM: 143030

KEGG: hsa:928

STRING: 9606.ENSP00000009180

UniGene: Hs.114286