Recombinant Mouse Programmed cell death 1 ligand 1(Cd274),partial

1. Immunogenic mouse neuroblastoma acquires adaptive immune resistance by up-regulating PD-L1 expression, whereas PD-L1 is of lesser consequence in nonimmunogenic neuroblastoma tumors. Combining PD-L1 checkpoint inhibition with whole tumor cell/anti-CTLA-4 vaccination enhanced tumor cell killing, cured mice with established tumors, and induced long-term immune memory (6 months). PMID: 29377881
2. Data show that programmed cell death 1 ligand 1 (PD-L1) from disparate cellular sources, including tumour cells, myeloid or other immune cells can similarly modulate the degree of cytotoxic T-cell function and activity in the tumour microenvironment. PMID: 28220772
3. IFNbeta activates neuronal PI3K/Akt signalling and Akt binds to transcription factor FoxA1 that translocates to the nucleus and induces PDL1. Conversely, inhibition of PI3K/Akt, FoxA1 and PDL1 blocked neuronal ability to generate FoxA1(+)Tregs. PMID: 28436428
4. suppression of inflammatory responses and T cells apoptosis were observed with elevated expression of IRAK-M and PDL-1, and interference and neutralization of these 2 molecules led to partly reversed suppression of inflammation. PMID: 29995830
5. The present work shows the role of SOCS1 in murine melanoma development and the potential of SOCS1-silenced tumor cells in raising an effective anti-melanoma immune response. PMID: 28079159
6. miR-142 could attenuate cecal ligation and puncture-induced inflammation and thus sepsis via targeting PD-L1 in macrophages. PMID: 29793310
7. T-cell activation mediates the immunopreventive effects of anti-PD-1; PD-1 on T cells interacts with the PD-1 ligand PD-L1 on cancer cells PMID: 29018057
8. an enhanced expression of PD-L1 was observed besides an increased production of IFN-gamma by TH2 cells. PMID: 28917991
9. Study demonstrated that PD-L1 expression is up-regulated in the salivary glands of female NOD mice during the developmental phase of Sjgren's syndrome, which in turn hinders the development and onset of this disease in a negative feedback fashion. PMID: 27966604
10. PD-L1 expression on tumor cells suppressed antigen-driven TNF production by CD8(+) T cells, which could be antagonized through PD-1 blockade PMID: 28665401
11. Anti-PD-1/PD-L1 therapy inhibited CMT167 orthotopic lung tumors by 95%. .Silencing PD-L1 expression in CMT167 cells resulted in smaller orthotopic tumors that remained sensitive to anti-PD-L1 therapy, whereas implantation of CMT167 cells into PD-L1(-) mice blocked orthotopic tumor growth, indicating a role for PD-L1 in both the cancer cell and the microenvironment. PMID: 28819064
12. In estrogen receptor negative breast cancer cells targeting of IL-17A inhibited PDL1 expression in the tumor microenvironment, decreasing the percentage of Treg cells in tumor-infiltrating lymphocytes, and promoting CD4+ and CD8+ T cells to secrete interferon gamma. PMID: 27935862
13. Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8+ T Cells co-expressing PD-1 and LAG-3 inhibitory receptors. PMID: 27835902
14. Genetic ablation of a single immune-regulatory molecule in this model [i.e., B7-homolog 1 (B7-H1, PD-L1)] not only significantly increased incidence of spontaneous CNS autoimmunity and aggravated disease course, especially in the later stages of disease, but also importantly resulted in encephalitogenic T-cell infiltration and lesion formation in normally unaffected brain regions. PMID: 27671636
15. Studied the possible role of PD-L1 on malignant melanoma initiating cells (MMICs). Found blocking of PD-L1 in melanoma cell lines impaired tumorsphere formation and induced the apoptosis. Also, blocking PD-L1 inhibited tumor growth in vivo. PMID: 29250533
16. B7-H1 induction in keratinocytes may play a crucial role in the protection from CD4+ T cell-mediated tissue inflammation by exogenous antigens delivered from the mucosal surface in oral cavity PMID: 27731324
17. Interferon-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells. PMID: 27295261
18. Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR-155, Pdcd1, Pdcd1l1, and Ctla4 appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 = programmed cell death 1 protein; Pdcd1l1 = programmed cell death 1 ligand 1 protein; Ctla4 = cytotoxic T-lymphocyte-associated protein 4] PMID: 28912267
19. spleen-derived IFN-gamma induces generation of PD-L1(+)-suppressive neutrophils. PMID: 28974543
20. It was concluded that down-regulated expression of miR-143 and up-regulation of its direct target B7H1 may indicate a novel therapeutic method for radiation-induced thymic lymphoma by increased expression of miR-143 or inhibition of B7H1. PMID: 28736328
21. HDAC6 inhibition reduces tumor growth and PD-L1 production in vivo. PMID: 26775640
22. mediates an innate checkpoint to control adaptive T helper responses PMID: 28747424
23. PD-L1 selectively enhances T cell-mediated immune responses, driving graft-versus-host disease lethality and suggesting a context-dependent function of the PD-1/PD-L1 axis PMID: 27294527
24. Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta activation. PMID: 28423181
25. These results indicate that the outcome of PD-L1-mediated signaling in CD8+ T cells depends on the presence or absence of CD4+ T cells, the nature of the interacting receptor expressed by CD8+ T cells, and the tissue environment in which the signaling occurs. PMID: 28414296
26. findings identify a previously unrecognized role of PD-L1 as an endogenous pain inhibitor and a neuromodulator. PMID: 28530662
27. reduced cytotoxicity as a key mechanism by which tumor PD-L1 suppresses antitumor immunity and demonstrate that tumor PD-L1 is not just a marker of suppressed antitumor immunity. PMID: 28302645
28. Apigenin inhibits IFN-gamma-induced PD-L1 expression by breast cancer cells, potentially rendering BC cells that lack constitutive PD-L1 expression more susceptible to T cellmediated anti-tumor immune responses. PMID: 27378243
29. results reveal a novel CD40-dependent regulation of PD-L1 trafficking induced upon TLR3 signaling that dictates its inhibitory activity. PMID: 27911948
30. IL-6 and PD-L1 blockade combination inhibits hepatocellular carcinoma cancer development in a mouse model. PMID: 28254435
31. PD-1/PD-L1 plays a crucial role in maintaining immune tolerance induced by UVB-iDCs, as well as in actively controlling effector T cells specific to alloantigens. PMID: 27556047
32. Data show that Qiyusanlong decoction (QYSL) can moderately inhibit the growth of the transplanted tumor by decreasing programmed death 1 and programmed death ligand 1 (PD-1/PD-L1) level. PMID: 27371844
33. Expression of PD-L1 is correlated with the severity of periodontitis in the mouse model of experimental periodontitis. PMID: 26847035
34. Loss of Cdk5 results in persistent expression of the PD-L1 transcriptional repressors, the interferon regulatory factors IRF2 and IRF2BP2, which likely leads to reduced PD-L1 expression on tumors. PMID: 27463676
35. addition to inhibiting T cells, hepatic stellate cells (HSCs) concurrently inhibit B cells via PD-L1; this direct B cell-inhibitory activity of HSCs should contribute to the mechanism by which HSCs maintain the liver's immune homeostasis PMID: 26755818
36. The results demonstrated that blockade of PD-1/B7H1 pathway could promote mouse NK cells to kill the GL261GSCs, and the PD-1-inhibited NK cells could be a feasible immune therapeutic approach against Glioblastoma multiforme. PMID: 26266810
37. These findings provide evidence for a novel immune escape mechanism during acute retroviral infection based on PD-L1 expression levels on virus infected target cells PMID: 26484769
38. These results suggest a novel and specific role for PspA in modulating immune responses against S. pneumoniae by regulating PD-L1 expression. PMID: 26214513
39. Upregulation of PD-1 and PD-L1 was associated with marked increases in GADD153 during myocardial ischemic reperfusion injury. PMID: 25902191
40. Breg cells can suppress through the PD-1/PD-L1 pathway in limiting the differentiation and function of TFH cells PMID: 25609381
41. Programmed death 1/programmed death ligand 1 pathway likely plays a crucial role in the mechanisms underlying spontaneous tolerization of B cells responding to ABO-blood group antigens in liver transplantation. PMID: 26247556
42. B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway. PMID: 26378076
43. the upregulation of IFN-beta in DCs induces the up-regulation of coinhibitory molecules B7H1 and GITRL, which cause an impaired activation of naive Ag-specific T cells PMID: 25144375
44. IL-10 released from 18-month old mice stimulated the expression of B7-H1 on myeloid-derived suppressor cells PMID: 25479230
45. PD-L1 expression is increased on tumor cells by direct contact with BM-derived CD11b-positive cells through the p38 signaling pathway. PMID: 25889536
46. Our study defines PD-1 upregulated on Treg cells and its interaction with PD-1 ligand on effector T cells as one cause for the potent T cell suppression and proposes the role of PD-1 on Treg cells. PMID: 25934860
47. Transduction of T cells with this new PD-1-CD28 receptor has the potential of breaking the PD-1-PD-L1-immunosuppressive axis in ACT. PMID: 26105028
48. data reveal that PD-L1 is a critical modulator of Tregs' ability to suppress iALI, and this appears to involve SHP-1 activation. PMID: 25057927
49. In experimental autoimmune uveitis, inducible Tregs use a PD-1/PD-L1 mechanism to suppress the disease. PMID: 25877928
50. Immunological in vivo effects of B7-H1 deficiency PMID: 25173046
51. the results of this study suggest that BMSCs transplantation, especially on multiple dosing, may exert immunosuppression effect to ameliorate EAH through the inhibition of IL-17 and up-regulation of PD-L1. PMID: 25445618
52. data strongly suggest that PD-L1, expressed on activated target keratinocytes presenting autoantigens, regulates autoaggressive CD8 T cells, and inhibits the development of mucocutaneous autoimmune diseases. PMID: 25047812
53. Splenic DCs might suppress the stimulation of T lymphocytes in MODS mice through the PD-L1/PD-1 pathway, which would induce immunosuppression and the pathogenesis of MODS PMID: 25299080
54. Results demonstrate that microglia and astrocytes control antiviral T-cell responses and suggest a therapeutic potential of PD1: PD-L1 modulation to manage the deleterious consequences of uncontrolled neuroinflammation PMID: 24890099
55. mesenchymal stem cells expressing B7-H1 mediates the immune tolerance to cardiac allografts in recipients receiving mesenchymal stem cell and rapamycin combination therapy. PMID: 24978830
56. The role of neurogenin 3 and PD-L1 in the genesis of neo-islets in NOD mice is reported. PMID: 25332429
57. These results indicate that B7H1/CD80 interaction augments Tcon cell proliferation, IL-2 production, and expression of PD-1, which leads to increased apoptosis PMID: 25488990
58. In vivo blockade of PD-1/PD-L1 pathway on CD8 T cells, in combination with ETV treatment and DNA vaccination, potently enhanced the function of virus-specific T cells. PMID: 24391505
59. These results indicate that the PD-1 pathway plays a pivotal regulatory role in the development of Theiler murine encephalomyelitis virus induced demyelinating disease. PMID: 25027060
60. The DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8 T cells independently of PD-1 and PD-L1. PMID: 24021877
61. Disruption of CXCR2-mediated myeloid derived suppressor cell tumor trafficking enhances anti-PD1 efficacy in rhabdomyosarcomas. PMID: 24848257
62. the scFv demonstrated inhibitory biological activity comparable to an antagonistic monoclonal antibody, providing an alternative agent for blocking PD-1/PD-L1 signaling. PMID: 24215864
63. Our novel observations are the first to implicate PD-L1 involvement in worsening outcome of experimental stroke PMID: 24015822
64. PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. PMID: 24778419
65. Up-regulated expression of IDO and PD-L1, as well as recruitment of regulatoryT cells, in the tumor microenvironment depended on the presence of CD8(+) T cells. PMID: 23986400
66. PD-L1 has a role in sepsis-induced liver injury (as shown in a mouse cecal ligation and puncture model) PMID: 24324295
67. PD-L1 plays an essential role in the neuroprotection afforded by transferred regulatory T cells against cerebral ischemia PMID: 24496394
68. Mice deficient in coinhibitory PD-L1 or PD-1 molecules (PD-L1(-/-) and PD-1(-/-) mice), were used to study induction of preproinsulin (ppins)-specific CD8 T-cell responses and experimental autoimmune diabetes. PMID: 23977133
69. These data demonstrate the potential of B7-H1-based vaccine as a therapeutic agent for the treatment of cancer overexpressing B7-H1. PMID: 23970300
70. PD-L1 is upregulated in the tumor microenvironment after ionizing radiation, showing that there is a close interaction between IR, T cells, and the PD-L1/PD-1 axis PMID: 24382348
71. B7-H1 is upregulated extensively on various immune cells during sepsis and B7-H1 gene deficiency protects mice from the lethality of sepsis. B7-H1 contributes to septic morbidity in fashion distinct from PD-1. PMID: 24379123
72. PD-L1, contributes to the defective CD8(+) T cell response to Chlamydia trachomatis. Deletion or inhibition of PD-L1 restores the CD8(+) T cell response and enhances C. trachomatis clearance. PMID: 24353266
73. Blockade of airway epithelial PDL-1 improves CD8 T cell function. PMID: 24067957
74. uncover an underappreciated pathological aspect of PD-1:PD-L1 ligation during inflammation that is independent of its normal, immune-suppressive activity PMID: 23766529
75. These results strongly suggest that the expression of PD-1 and PDL-1 in the central nervous system is upregulated following Theiler's murine encephalomyelitis virus infection and requires IL-6 signaling. PMID: 23966393
76. the higher expression of PD-L1 in the muscle and kidney (non-target tissues) plays a protective role in skeletal muscle during acute graft-versus-host disease. PMID: 23593203
77. lack of PD-L1 expression by iNKT cells reduces the sensitivity to influenza A PMID: 23555047
78. the results presented here demonstrate that recruitment and expression of MHC-II, CD80, CD86, PDL1, and PD-L2 in M of peritoneal cavity in T. crassiceps early at infection is associated to the sex of the host. PMID: 23533995
79. PD-L1 plays an important costimulatory role for antigen-specific CD8 T cells during LM infection perhaps through a distinct receptor or interaction epitope PMID: 23409193
80. This study demonstrated that CD4 T-cell helper functions contribute significantly to enhanced CD8 T-cell activity in B7-H1-/- mice, in addition to the direct relief of CD8 T cells from PD-1:B7-H1 inhibitory signaling within the CNS. PMID: 23237504
81. B7-H1 protein may play a role in the immune privilege following corneal allograft transplantation in mice. PMID: 22699081
82. Data indicate that lymphatic endothelial cells (LECS)-induced deletion is based on programmed cell death-1 (PD-1) ligand 1 (PD-L1) engagement of PD-1. PMID: 22993390
83. Herpes simplex virus-1 infection increases the expression PD-L1, its blocking is a therapeutic strategy for herpes simplex. PMID: 22808056
84. A cell-to-cell contact-dependent mechanism in the selective immunosuppression of mesenchymal stem cells on mature Th17 cells is realized through up-regulation of PD-L1. PMID: 23028899
85. The B7H1 and GITRL molecules may play an important role in TGF-beta-induced Treg expansion of lung cancer microenvironment. PMID: 22614805
86. PD-L1 expression in intestinal lamina propria was investigated and it was found that IgA plasma cells were major PD-L1 expressing cells. PMID: 22906740
87. PD-L1 delivers an immunoinhibitory signal, suppressing T cell activation. PMID: 22381170
88. IL-27-dependent induction of PD-L1 on naive cells inhibited IL-17 production in an untreated population of differentiating Th17 cells. Th17-cell-mediated autoimmune encephalomyelitis was lessened by IL-27-treated PD-L1 T-cells. PMID: 22726954
89. IL-27 promotes cell surface expression of B7-H1 (Cd274) in liver plasmacytoid DCs (pDCs), which in turn increases the incidence of CD4+ T cells expressing Foxp3. PMID: 22508931
90. The Tim-3 and PD-L1-mediated signaling can significantly reduce pathologies in the upper genital tract without suppressing immunity against chlamydial infection. PMID: 22168579
91. in vivo data demonstrated that B7-H1 was absolutely required for myeloid-derived suppressor cells to exert immune regulatory activity and induction of T regulatory cells PMID: 22179405
92. B7-H1 expression in parenchymal cells is required for tolerizing infiltrating T cells and preventing continued tissue injury of graft-versus-host disease in recipients. PMID: 22156590
93. PD-L1 blockade by murine PD-L1 antibodies significantly improves survival of mice with cecal ligation and puncture-induced (CLP) sepsis. PMID: 21118528
94. upregulation of B7-H1 on primed T cells helps effector T cells survive the contraction phase and consequently generate optimal protective immunity. PMID: 22025548
95. characterization of Salmonella-modulated diabetes prevention in NOD mice; PD-L1, an inhibitory receptor, was upregulated throughout infection and protection against T1D was lost if PD1/PD-L1 interaction was ablated PMID: 21792877
96. The PD-L1:B7-1 pathway inhibits potentially pathogenic self-reactive effector CD4-positive and CD8-positive T cell responses in vivo, which is particularly important during the later phases of diabetogenesis. PMID: 21697456
97. Review discusses the diverse functions of B7-H1 in carcinogenesis and cancer progression. PMID: 21730022
98. Graft tissue expression of B7-H1 plays a critical role in regulating inflammatory responses during liver transplantation-induced hepatic ischemia/reperfusion injury. PMID: 21503939
99. Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice. PMID: 20802088
100. LGP2 overexpression decreases neuronal B7-H1 expression. PMID: 21525357

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KEGG: mmu:60533

STRING: 10090.ENSMUSP00000016640

UniGene: Mm.245363