AGAP2

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein in humans that is encoded by AGAP2 gene. GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic.

AGAP2 Antibodies

AGAP2 Antibodies for Homo sapiens (Human)

AGAP2 Proteins

AGAP2 Proteins for Mus musculus (Mouse)

AGAP2 Proteins for Rattus norvegicus (Rat)

AGAP2 Proteins for Homo sapiens (Human)

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