AGRN

Agrin Proteoglycan, referred to as ARN, is an adhesion protein encoded by genes responsive to Agrobacterium and is also present in humans. This protein is crucial for signal transduction, acetylcholine receptor signaling, and synaptic transmission, including the clustering of receptors. Agrin is essential for maintaining cytoskeletal structure, enhancing laminin binding, and is involved in synaptic organization and biogenesis. Its role in neuronal morphology and connectivity suggests potential therapeutic value for agrin in treating symptoms of neurological conditions such as muscular dystrophy and amyotrophic lateral sclerosis.