Interferon-inducible protein AIM2 is a protein in humans that is encoded by AIM2 gene. Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
The following AIM2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
AIM2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA001499GA01HU | AIM2 Antibody |
Human | ELISA,WB |
CSB-PA284032 | AIM2 Antibody |
Human | ELISA,WB |
CSB-PA000838 | AIM2 Antibody |
Human | WB, IHC, IF, ELISA |
CSB-PA858560 | AIM2 Antibody |
Human | ELISA,IHC |
CSB-PA001499LA01HU | AIM2 Antibody |
Human | ELISA, WB, IHC, IF |
CSB-PA001499LB01HU | AIM2 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA001499LC01HU | AIM2 Antibody, FITC conjugated |
Human | |
CSB-PA001499LD01HU | AIM2 Antibody, Biotin conjugated |
Human | ELISA |
AIM2 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA328021XA01SVG | AIM2 Antibody |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ELISA, WB (ensure identification of antigen) |
AIM2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP001499HU CSB-EP001499HU CSB-BP001499HU CSB-MP001499HU CSB-EP001499HU-B |
Recombinant Human Interferon-inducible protein AIM2 (AIM2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AIM2 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Code | Product Name | Source |
---|---|---|
CSB-YP328021SVG CSB-EP328021SVG CSB-BP328021SVG CSB-MP328021SVG CSB-EP328021SVG-B |
Recombinant Saccharomyces cerevisiae Protein AIM2 (AIM2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AIM2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP845977MO CSB-EP845977MO CSB-BP845977MO CSB-MP845977MO CSB-EP845977MO-B |
Recombinant Mouse Interferon-inducible protein AIM2 (Aim2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |