E3 ubiquitin-protein ligase AMFR is a protein in humans that is encoded by AMFR gene. E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.
The following AMFR reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
AMFR Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA001665GA01HU | AMFR Antibody |
Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA333164LA01HU | AMFR Antibody |
Human | ELISA, WB, IHC |
AMFR Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF886413MO | Recombinant Mouse E3 ubiquitin-protein ligase AMFR(Amfr) |
in vitro E.coli expression system |
CSB-YP886413MO1 CSB-EP886413MO1 CSB-BP886413MO1 CSB-MP886413MO1 CSB-EP886413MO1-B |
Recombinant Mouse E3 ubiquitin-protein ligase AMFR(Amfr),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AMFR Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF892337HU | Recombinant Human E3 ubiquitin-protein ligase AMFR(AMFR) |
in vitro E.coli expression system |
CSB-YP892337HU1 CSB-BP892337HU1 |
Recombinant Human E3 ubiquitin-protein ligase AMFR(AMFR),partial |
Yeast Baculovirus |