ANKRD55

ANKRD55 (Ankyrin Repeat Domain 55), also known as KIAA1751, is an ankyrin repeat-containing protein that mediates protein-protein interactions. It regulates immune homeostasis by modulating NF-κB and JAK-STAT signaling pathways, influencing T cell activation and the secretion of pro-inflammatory cytokines like TNF-α and IL-6.
Genetic variants of ANKRD55 are strongly associated with autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis) via genome-wide association studies. Direct therapeutic targeting remains preclinical, but its role as a risk factor drives research into modulating its activity to mitigate excessive inflammation, offering potential future avenues for autoimmune disease treatments.