Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
The following ARID1A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ARID1A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA040400 | ARID1A Antibody |
Human,Mouse | ELISA,IHC |
CSB-PA226311 | ARID1A Antibody |
Human,Mouse | ELISA,WB |
CSB-PA002058LA01HU | ARID1A Antibody |
Human | ELISA, IHC |
CSB-PA002058LB01HU | ARID1A Antibody, HRP conjugated |
Human | ELISA |
ARID1A Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP002058MO CSB-EP002058MO CSB-BP002058MO CSB-MP002058MO CSB-EP002058MO-B |
Recombinant Mouse AT-rich interactive domain-containing protein 1A (Arid1a), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ARID1A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP002058HU CSB-EP002058HU CSB-BP002058HU CSB-MP002058HU CSB-EP002058HU-B |
Recombinant Human AT-rich interactive domain-containing protein 1A (ARID1A), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP002058HU1 | Recombinant Human AT-rich interactive domain-containing protein 1A (ARID1A), partial |
E.coli |
CSB-BP002058HU1 | Recombinant Human AT-rich interactive domain-containing protein 1A (ARID1A), partial |
Baculovirus |