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Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer.
The following ARID5B reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ARID5B Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA002067XA01DIL | arid5b Antibody |
Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
ARID5B Proteins for Bos taurus (Bovine)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002067BO CSB-EP002067BO CSB-BP002067BO CSB-MP002067BO CSB-EP002067BO-B |
Recombinant Bovine AT-rich interactive domain-containing protein 5B (ARID5B), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ARID5B Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002067DO CSB-EP002067DO CSB-BP002067DO CSB-MP002067DO CSB-EP002067DO-B |
Recombinant Dog AT-rich interactive domain-containing protein 5B (ARID5B), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ARID5B Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP002067DIL CSB-EP002067DIL CSB-BP002067DIL CSB-MP002067DIL CSB-EP002067DIL-B |
Recombinant Danio rerio AT-rich interactive domain-containing protein 5B (arid5b), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ARID5B Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP623937HU CSB-EP623937HU CSB-BP623937HU CSB-MP623937HU CSB-EP623937HU-B |
Recombinant Human AT-rich interactive domain-containing protein 5B (ARID5B), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ARID5B Proteins for Gallus gallus (Chicken)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP716952CH CSB-EP716952CH CSB-BP716952CH CSB-MP716952CH CSB-EP716952CH-B |
Recombinant Chicken AT-rich interactive domain-containing protein 5B (ARID5B), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ARID5B Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP805924MO CSB-EP805924MO CSB-BP805924MO CSB-MP805924MO CSB-EP805924MO-B |
Recombinant Mouse AT-rich interactive domain-containing protein 5B (Arid5b), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
