BCAM

BCAM (Basal Cell Adhesion Molecule), also known as Lutheran glycoprotein (Lu) or CD239, is an immunoglobulin superfamily transmembrane receptor. It binds laminin α5 in the extracellular matrix to mediate cell adhesion, migration, and mechanotransduction. BCAM is functionally linked to the PI3K/AKT and ERK/MAPK signaling pathways, influencing cytoskeletal reorganization and cellular responses to shear stress. Clinically, BCAM is implicated in sickle cell disease by promoting vaso-occlusion through erythrocyte-endothelial interactions. Its overexpression in epithelial cancers (e.g., colorectal, ovarian) correlates with metastasis and poor prognosis. Therapeutic targeting of BCAM-laminin interactions using monoclonal antibodies (e.g., BCAM-05) is under preclinical investigation for sickle cell disease, while small-molecule inhibitors are being explored in oncology to disrupt BCAM-mediated tumor dissemination.

Popular Product:

BCAM Antibody (CSB-PA341920LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA341920LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA341920LA01HU at dilution of 1:100

Immunofluorescence staining of HepG2 cells with CSB-PA341920LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The following BCAM reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

BCAM Antibodies

BCAM Proteins

BCAM Antibodies

BCAM Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA005864	BCAM Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA908140	BCAM Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA930807	BCAM Antibody	Human	ELISA,WB
CSB-PA341920LA01HU	BCAM Antibody	Human	ELISA, IHC, IF

BCAM Proteins

BCAM Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP341920HU CSB-EP341920HU CSB-BP341920HU CSB-MP341920HU CSB-EP341920HU-B	Recombinant Human Basal cell adhesion molecule (BCAM), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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