CCNA1

CCNA1, also known as cyclin A1, is a protein coding gene that plays a crucial role in cell cycle regulation. It primarily functions in the meiotic cell cycle but also contributes to somatic cell cycle progression. CCNA1 binds to CDK2 and CDC2 kinases, regulating cell cycle transitions and interacting with cell cycle regulators like Rb family proteins, E2F-1, and p21 family proteins. Dysregulation of CCNA1 is implicated in various solid tumors, including esophageal squamous cell carcinoma, where it is associated with poor prognosis and serves as a potential therapeutic target. CCNA1's involvement in transforming growth factor-beta (TGF-beta) pathway suppression suggests its role in osteoporosis inhibition. Research into CCNA1 methylation and its correlation with cancer development has led to potential diagnostic and prognostic markers, as well as avenues for drug development.