CCND2

Cyclin D2 (encoded by CCND2) is a critical G1-phase cell cycle regulator. Its full name is Cyclin D2, with aliases including D2-type cyclin. It forms active complexes with CDK4/6, phosphorylating the retinoblastoma protein (Rb) to release E2F transcription factors, thereby promoting cell cycle progression into the S phase.
Dysregulation of Cyclin D2 is linked to PI3K/AKT and MAPK signaling pathways. Overexpression is associated with non-Hodgkin lymphoma, breast, and ovarian cancers, driving uncontrolled proliferation. CDK4/6 inhibitors like palbociclib target Cyclin D2-CDK complexes, showing clinical efficacy in treating these malignancies as a key therapeutic approach.