CD30

CD30, or differentiation group 30, is a type I transmembrane protein that is a member of the tumour necrosis factor receptor superfamily.CD30 is expressed in a wide range of lymphocytes, and is particularly highly expressed in Hodgkin's lymphoma and certain non-Hodgkin's lymphomas. Its mechanism of action involves the activation of signalling pathways such as nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK), which promotes the survival and proliferation of tumour cells.CD30 plays a regulatory role in the differentiation, maturation, and activation of lymphocytes as well as serving as an important target for the diagnosis and treatment of lymphoma.