CDO1

CDO1 encodes cysteine dioxygenase type 1, a key enzyme in cysteine catabolism that catalyzes the conversion of cysteine to cysteine sulfinate using molecular oxygen. It regulates cellular redox balance by maintaining cysteine homeostasis and preventing oxidative stress. Common aliases include CDO.
CDO1 interacts with pathways like the transsulfuration pathway and glutathione synthesis. Its dysregulation is linked to cancer, particularly downregulation in breast and lung cancers, and neurodegenerative diseases. Limited drug exists, with focus on modulators targeting its enzymatic activity for cancer therapy.