Cytochrome c oxidase subunit 2 (COX2), encoded by the mitochondrial gene CDS2, is a core component of the electron transport chain complex IV. It catalyzes oxygen reduction to water, facilitating ATP production via oxidative phosphorylation. COX2 interacts with COX1 and COX3 to form the catalytic core, and its dysfunction impairs mitochondrial respiration.
Mutations in CDS2 are linked to mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). No targeted drugs exist, but therapeutic strategies focus on mitochondrial function enhancement, such as coenzyme Q10 supplementation and mitochondrial replacement therapies, though clinical efficacy remains investigational.
CDS2 Antibody (CSB-PA005123LA01HU)
Validated Data
Western Blot
Positive WB detected in: HepG2 whole cell lysate, Hela whole cell lysate, MCF-7 whole cell lysate
All lanes: CDS2 antibody at 6µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 30 kDa
Observed band size: 52 kDa
IHC image of CSB-PA005123LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA005123LA01HU diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
The following CDS2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CDS2 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA005123GA01HU | CDS2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA005123LA01HU | CDS2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA005123LB01HU | CDS2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA005123LC01HU | CDS2 Antibody, FITC conjugated | Human | |
| CSB-PA005123LD01HU | CDS2 Antibody, Biotin conjugated | Human | ELISA |
CDS2 Antibodies for Arabidopsis thaliana (Mouse-ear cress)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA678268XA01DOA | CDS2 Antibody | Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
CDS2 Proteins for Rattus norvegicus (Rat)
| Code | Product Name | Source |
|---|---|---|
| CSB-CF845999RA | Recombinant Rat Phosphatidate cytidylyltransferase 2 (Cds2) | in vitro E.coli expression system |
| CSB-YP845999RA1 CSB-EP845999RA1 CSB-BP845999RA1 CSB-MP845999RA1 CSB-EP845999RA1-B |
Recombinant Rat Phosphatidate cytidylyltransferase 2 (Cds2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDS2 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-CF860808MO | Recombinant Mouse Phosphatidate cytidylyltransferase 2 (Cds2) | in vitro E.coli expression system |
| CSB-YP860808MO1 CSB-EP860808MO1 CSB-BP860808MO1 CSB-MP860808MO1 CSB-EP860808MO1-B |
Recombinant Mouse Phosphatidate cytidylyltransferase 2 (Cds2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDS2 Proteins for Bos taurus (Bovine)
| Code | Product Name | Source |
|---|---|---|
| CSB-CF005123BO | Recombinant Bovine Phosphatidate cytidylyltransferase 2 (CDS2) | in vitro E.coli expression system |
| CSB-YP005123BO1 CSB-EP005123BO1 CSB-BP005123BO1 CSB-MP005123BO1 CSB-EP005123BO1-B |
Recombinant Bovine Phosphatidate cytidylyltransferase 2 (CDS2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CDS2 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-CF005123HU | Recombinant Human Phosphatidate cytidylyltransferase 2 (CDS2) | in vitro E.coli expression system |
| CSB-YP005123HU1 CSB-EP005123HU1 CSB-BP005123HU1 CSB-MP005123HU1 CSB-EP005123HU1-B |
Recombinant Human Phosphatidate cytidylyltransferase 2 (CDS2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |