CEACAM6

CEACAM6, carcinoembryonic antigen-associated cell adhesion molecule 6, alias NCA, CEAL, CD66c, NCA-50/90, is encoded by the human CEACAM6 gene, which is located on chromosome 19.
CEACAM6 is an immunoglobulin superfamily protein expressed mainly on the epithelial surface and in myeloid cells, and plays an important role in cancer progression by inhibiting apoptosis, promoting drug resistance and facilitating cancer cell invasion and metastasis. Its mechanism of action involves the regulation of epithelial mesenchymal transition (EMT), tumor invasion and metastasis, as well as participation in tumor cell adhesion and drug resistance by affecting the Src/PI3K/Akt signaling pathway.
Overexpression of CEACAM6 in a variety of cancers, including lung, breast, colorectal and hepatocellular carcinoma, is associated with poor prognosis and is a promising cancer marker and therapeutic target.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM6 at 2 μg/mL can bind Human CEACAM8 (CSB-MP005168HU), the EC₅₀ is 144.7-223.8 ng/mL.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM6 at 2 μg/mL can bind Anti- CEACAM5/CEACAM6 recombinant antibody (CSB-RA005165MA2HU), the EC₅₀ is 0.9430-1.377 ng/mL.

CEACAM6 Antibody (CSB-PA005166LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA005166LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA005166LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6) ELISA kit (CSB-EL005166HU)

Validated Data

Code: CSB-EL005166HU

Size: 96T,5×96T,10×96T

Sensitivity: 0.33 ng/mL

Detection Range: 0.83 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following CEACAM6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CEACAM6 Antibodies

CEACAM6 Proteins

CEACAM6 ELISA Kits

CEACAM6 Antibodies

CEACAM6 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA999004	CEACAM6 Antibody	Human	ELISA,IHC
CSB-PA832895	CEACAM6 Antibody	Human	ELISA,IHC
CSB-PA005166LA01HU	CEACAM6 Antibody	Human	ELISA, IHC, IF

CEACAM6 Proteins

CEACAM6 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP005166HU CSB-BP005166HU CSB-MP005166HU CSB-EP005166HU-B	Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP005166HU	Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)	E.coli
CSB-MP005166HU	Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) (Active)	Mammalian cell

CEACAM6 ELISA Kit

CEACAM6 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL005166HU	Human Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6) ELISA kit	serum, plasma, tissue homogenates	0.33 ng/mL

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CEACAM6

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