CHMP4A

CHMP4A encodes Charged Multivesicular Body Protein 4A, also known as Chromatin Modifying Protein 4A. This protein is a key component of the ESCRT - III complex, which is vital for the formation of multivesicular bodies and the sorting of ubiquitinated membrane proteins. It participates in the endosomal sorting pathway, facilitating the degradation of membrane proteins.
Alterations in CHMP4A have been linked to neurodegenerative diseases and some types of cancer. Given its role in disease - related pathways, it has become an attractive target for drug discovery. Current research is focused on developing small - molecule inhibitors to modulate its function, though significant progress still remains to be made.