CHMP4C Research Reagents

Charged multivesicular body protein 4c is a protein in humans that is encoded by CHMP4C gene. Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage

The following CHMP4C reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CHMP4C Antibodies

CHMP4C Antibodies for Homo sapiens (Human)

CHMP4C Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

CHMP4C Proteins

CHMP4C Proteins for Rattus norvegicus (Rat)

CHMP4C Proteins for Xenopus laevis (African clawed frog)

CHMP4C Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

CHMP4C Proteins for Homo sapiens (Human)

CHMP4C Proteins for Mus musculus (Mouse)

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