CLEC14A

The gene CLEC14A encodes a protein known as C-type lectin domain-containing protein 14A. Also referred to as CLEC14A, this protein plays a crucial role in regulating angiogenesis and bone formation. It functions by interacting with other molecules to modulate cellular processes, particularly those related to the immune system and vascular development. CLEC14A is involved in various signaling pathways, including those related to angiogenesis and bone remodeling. Its dysregulation is associated with several diseases, such as cancer and osteoporosis. In terms of drug development, there is ongoing research into antibody-drug conjugates targeting CLEC14A for the treatment of solid tumors, leveraging its specific expression in tumor endothelial cells.