DAP10

DAP10, also known as DNAX-activation protein 10, is a transmembrane adaptor protein. It is commonly recognized by its alias, p10. Functionally, DAP10 associates with activating receptors on natural killer (NK) cells and subsets of T cells. It activates intracellular signaling pathways mainly via the phosphatidylinositol 3-kinase (PI3K) pathway.
Altered DAP10 function has been linked to certain immune - related diseases, potentially disrupting immune surveillance. In drug development, researchers are exploring ways to modulate DAP10 - mediated signaling for therapeutic purposes, aiming to enhance immune responses against tumors or manage autoimmune disorders. Further research is needed to translate these findings into clinical applications.