DDR2

DDR2, also known as discoidin domain receptor 2, is a transmembrane receptor tyrosine kinase. It is also commonly referred to as CD167b. DDR2 binds to collagen, leading to its autophosphorylation and subsequent activation of downstream signaling pathways. It is involved in cell adhesion, migration, and extracellular matrix remodeling. DDR2 is associated with various signaling pathways such as the MAPK and PI3K - AKT pathways.
Aberrant DDR2 activation has been linked to several diseases, including cancer and fibrosis. In cancer, it promotes tumor growth and metastasis. Regarding drug development, there is ongoing research to design DDR2 - targeted inhibitors. These inhibitors aim to block DDR2 activation and could potentially be used as novel therapies for DDR2 - related diseases.