Multifunctional ATP-dependent RNA helicase . The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities (Probable). Involved in transcription regulation. Positively regulates CDKN1A/WAF1/CIP1 transcription in an SP1-dependent manner, hence inhibits cell growth. This function requires its ATPase, but not helicase activity. CDKN1A up-regulation may be cell-type specific. Binds CDH1/E-cadherin promoter and represses its transcription. Potentiates HNF4A-mediated MTTP transcriptional activation; this function requires ATPase, but not helicase activity. Facilitates HNF4A acetylation, possibly catalyzed by CREBBP/EP300, thereby increasing the DNA-binding affinity of HNF4 to its response element. In addition, disrupts the interaction between HNF4 and SHP that forms inactive heterodimers and enhances the formation of active HNF4 homodimers. By promoting HNF4A-induced MTTP expression, may play a role in lipid homeostasis.
Recombinant Human ATP-dependent RNA helicase DDX3X (DDX3X)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP006621HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DDX3X.
BBased on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP006621HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) DDX3X.
The following DDX3X reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
DDX3X Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA006621GA01HU | DDX3X Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA006621DSR2HU | DDX3X Antibody |
Human | ELISA, IHC |
CSB-PA002106 | DDX3X Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA007707 | Phospho-DDX3X (T322) Antibody |
Human,Mouse,Rat | IHC, IF, ELISA |
CSB-PA006621LA01HU | DDX3X Antibody |
Human, Mouse, Rat | ELISA, WB, IHC, IF, IP |
CSB-PA006621LB01HU | DDX3X Antibody, HRP conjugated |
Human | ELISA |
DDX3X Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP006621HU CSB-MP006621HU CSB-EP006621HU-B |
Recombinant Human ATP-dependent RNA helicase DDX3X (DDX3X) |
Yeast Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP006621HU | Recombinant Human ATP-dependent RNA helicase DDX3X (DDX3X) |
E.coli |
CSB-BP006621HU | Recombinant Human ATP-dependent RNA helicase DDX3X (DDX3X) |
Baculovirus |
DDX3X Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP726783MO CSB-EP726783MO CSB-BP726783MO CSB-MP726783MO CSB-EP726783MO-B |
Recombinant Mouse ATP-dependent RNA helicase DDX3X (Ddx3x) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |