DIABLO

Diablo homolog, mitochondrial is a protein in humans that is encoded by DIABLO gene. Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

DIABLO Antibodies

DIABLO Antibodies for Homo sapiens (Human)

DIABLO Proteins

DIABLO Proteins for Xenopus laevis (African clawed frog)

DIABLO Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

DIABLO Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

DIABLO Proteins for Homo sapiens (Human)

DIABLO Proteins for Mus musculus (Mouse)

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