ECI2

ECI2 is a vital mitochondrial enzyme that specializes in the β-oxidation of unsaturated fatty acids, catalyzing the conversion of 3-cis and 3-trans-enoyl-coenzyme A esters into 2-trans-enoyl-coenzyme A intermediates. Central to lipid metabolism and the breakdown of polyunsaturated fatty acids, ECI2 also contributes to peroxisome lipid metabolism. Its endogenous antioxidant capabilities enable it to modulate cell differentiation, influence cell signaling, and reduce oxidative stress. Additionally, ECI2 has demonstrated the ability to inhibit the spread of colorectal cancer by impacting the tumor immune microenvironment, significantly reducing ether lipid production and IL-8 expression, which prevents the formation of neutrophil extracellular traps (NETs) and, consequently, the growth and metastasis of colorectal cancer.