Egl nine homolog 3 is a protein in humans that is encoded by EGLN3 gene. Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
The following EGLN3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
EGLN3 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA14797A0Rb | Egln3 Antibody |
Mouse, Rat | ELISA, WB |
EGLN3 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA007483GA01HU | EGLN3 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA880987ESR2HU | EGLN3 Antibody |
Human | ELISA, IHC |
CSB-PA040512 | EGLN3 Antibody |
Human,Mouse,Rat | ELISA,IHC |
EGLN3 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP733831RA CSB-EP733831RA CSB-BP733831RA CSB-MP733831RA CSB-EP733831RA-B |
Recombinant Rat Egl nine homolog 3 (Egln3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EGLN3 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP849640MO CSB-EP849640MO CSB-BP849640MO CSB-MP849640MO CSB-EP849640MO-B |
Recombinant Mouse Egl nine homolog 3 (Egln3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-RP147974m | Recombinant Mouse Egl nine homolog 3 protein (Egln3) |
E.coli |
EGLN3 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP880987HU CSB-EP880987HU CSB-BP880987HU CSB-MP880987HU CSB-EP880987HU-B |
Recombinant Human Egl nine homolog 3 (EGLN3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |