F2RL1

F2RL1 encodes the protein named protease-activated receptor 2 (PAR-2). It is also commonly known as coagulation factor II (thrombin) receptor-like 1. PAR-2 is activated by proteolytic cleavage, leading to the activation of various intracellular signaling pathways such as the MAPK and PI3K - AKT pathways.
This receptor is involved in multiple physiological and pathological processes. It has been associated with diseases like inflammation, pain, and cancer. In drug development, there are ongoing efforts to design PAR - 2 antagonists for potential treatment of these conditions, aiming to block its activation and the subsequent harmful effects.