FBXL12

The protein encoded by FBXL12 is an E3 ubiquitin ligase component belonging to the F-box protein family. It contains an F-box domain and leucine-rich repeats, functioning as a substrate recognition subunit in SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes. FBXL12 mediates ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle regulation and signal transduction.
FBXL12 has been implicated in regulating the Hippo signaling pathway by targeting LATS1/2 kinases for degradation, thereby modulating YAP/TAZ transcriptional activity. Dysregulation of FBXL12 is associated with cancer progression, particularly in colorectal and breast cancers, where its overexpression correlates with poor prognosis. Limited drug development targeting FBXL12 is currently underway, focusing on small molecule inhibitors to disrupt its ubiquitin ligase activity.