FBXO21

The protein encoded by FBXO21 is F-box only protein 21, an E3 ubiquitin ligase component that mediates substrate ubiquitination. It regulates protein turnover by recognizing specific substrates and facilitating their degradation via the ubiquitin-proteasome system.
FBXO21 participates in cell cycle progression and stress response pathways. Dysregulation is linked to cancer development, particularly breast and colorectal cancers. Preclinical studies explore its potential as a therapeutic target, though no specific drugs targeting FBXO21 are currently in clinical trials.