FBXO33

FBXO33, full name F-box only protein 33, is a member of the F-box protein family. As the substrate recognition subunit of the SCF (Skp1-Cullin1-F-box) E3 ubiquitin ligase complex, it mediates ubiquitination and proteasomal degradation of target proteins, regulating key processes like cell cycle progression (e.g., G1/S transition) and DNA damage repair.
Dysregulation of FBXO33 is associated with tumorigenesis—abnormal expression is found in breast cancer and non-small cell lung cancer, driving uncontrolled proliferation and impaired apoptosis. Drug development targeting its ubiquitination function remains preclinical, with small-molecule inhibitors being explored to correct aberrant protein degradation pathways for cancer therapy.