Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
The following FOXA2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FOXA2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA146585 | FOXA2 Antibody |
Human | ELISA,WB |
CSB-PA927484 | FOXA2 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA167678 | FOXA2 Antibody |
Human,Mouse,Rat | ELISA,WB |
FOXA2 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA184989XA01DIL | foxa2 Antibody |
Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
FOXA2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP008795MO CSB-EP008795MO CSB-BP008795MO CSB-MP008795MO CSB-EP008795MO-B |
Recombinant Mouse Hepatocyte nuclear factor 3-beta(Foxa2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOXA2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP008795RA CSB-EP008795RA CSB-BP008795RA CSB-MP008795RA CSB-EP008795RA-B |
Recombinant Rat Hepatocyte nuclear factor 3-beta(Foxa2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOXA2 Proteins for Oryzias latipes (Japanese rice fish) (Japanese killifish)
Code | Product Name | Source |
---|---|---|
CSB-YP008795OFH CSB-EP008795OFH CSB-BP008795OFH CSB-MP008795OFH CSB-EP008795OFH-B |
Recombinant Oryzias latipes Hepatocyte nuclear factor 3-beta(foxa2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOXA2 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Code | Product Name | Source |
---|---|---|
CSB-YP742473XBF CSB-EP742473XBF CSB-BP742473XBF CSB-MP742473XBF CSB-EP742473XBF-B |
Recombinant Xenopus tropicalis Forkhead box protein A2(foxa2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FOXA2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP897462HU CSB-EP897462HU CSB-BP897462HU CSB-MP897462HU CSB-EP897462HU-B |
Recombinant Human Hepatocyte nuclear factor 3-beta(FOXA2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |