FRMD5

FRMD5 (FERM Domain Containing 5) encodes a protein with a conserved FERM domain, mediating interactions between cytoskeletal components and plasma membrane proteins. Common aliases include FLJ20424 and FRMD5_HUMAN. It regulates cell adhesion, migration, and polarity by linking the actin cytoskeleton to membrane receptors, likely through modulating Rho GTPase signaling pathways.
Aberrant FRMD5 expression is linked to cancers like gastric and liver carcinoma, where its dysregulation may drive tumor cell invasion and metastasis. Drug development targeting FRMD5 remains in preclinical phases, focusing on blocking its downstream interactions to inhibit tumor progression, with no approved clinical agents to date.

Popular Product:

FRMD5 Antibody (CSB-PA773602LA01HU)

Validated Data

Western blot
All lanes: FRMD5 antibody at 16 μg/ml
Lane 1: Mouse kidney tissue
Lane 2: Mouse heart tissue
Lane 3: Mouse skeletal muscle tissue
Lane 4: Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 66, 64 kDa
Observed band size: 65 kDa

Immunohistochemistry of paraffin-embedded human glioma using CSB-PA773602LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA773602LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA773602LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The following FRMD5 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

FRMD5 Antibodies

FRMD5 Proteins

FRMD5 Antibodies

FRMD5 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA773602LA01HU	FRMD5 Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA773602LB01HU	FRMD5 Antibody, HRP conjugated	Human	ELISA
CSB-PA773602LC01HU	FRMD5 Antibody, FITC conjugated	Human
CSB-PA773602LD01HU	FRMD5 Antibody, Biotin conjugated	Human	ELISA

FRMD5 Proteins

FRMD5 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF773602HU	Recombinant Human FERM domain-containing protein 5 (FRMD5)	in vitro E.coli expression system
CSB-YP773602HU1 CSB-EP773602HU1 CSB-BP773602HU1 CSB-MP773602HU1 CSB-EP773602HU1-B	Recombinant Human FERM domain-containing protein 5 (FRMD5), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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