FZD4 Research Reagents

Frizzled-4 is a protein in humans that is encoded by FZD4 gene. Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

The following FZD4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

FZD4 Antibodies

FZD4 Antibodies for Homo sapiens (Human)

FZD4 Proteins

FZD4 Proteins for Mus musculus (Mouse)

FZD4 Proteins for Gallus gallus (Chicken)

FZD4 Proteins for Rattus norvegicus (Rat)

FZD4 Proteins for Xenopus laevis (African clawed frog)

FZD4 Proteins for Homo sapiens (Human)

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