H3L

H3L, also known as histone H3-like protein, is a conserved nuclear protein that participates in chromatin assembly and epigenetic regulation. It maintains genome stability and modulates gene transcription during cell proliferation and differentiation.
Dysregulation of H3L is closely associated with gliomas, neurodevelopmental disorders, and several epigenetic syndromes. It serves as a potential diagnostic marker and therapeutic target. Current research focuses on small-molecule epigenetic modulators and targeted inhibitors, with several candidates under preclinical evaluation for cancer and neurological diseases.