HJV

HJV, also known as hemojuvelin, is a key protein in iron metabolism. It is also commonly referred to as RGMc. HJV acts as a co - receptor for bone morphogenetic proteins (BMPs), enhancing BMP signaling. This signaling pathway is involved in upregulating the expression of hepcidin, which controls iron homeostasis.
Mutations in HJV are associated with juvenile hemochromatosis, a disease characterized by excessive iron absorption. In terms of drug development, research is focused on targeting the HJV - BMP - hepcidin axis to develop therapies for iron - related disorders, aiming to restore normal iron balance in patients.