Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Can both act as a transcriptional activator or repressor (By similarity). Plays a negative regulatory role in cells of the immune system (By similarity). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (By similarity). Positively regulates macroautophagy in dendritic cells.
The following IRF8 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IRF8 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011823GA01HU | IRF8 Antibody |
Human,Mouse | ELISA,WB,IHC |
CSB-PA011823ESR1HU | IRF8 Antibody |
Human | ELISA, IHC |
CSB-PA011823ESR2HU | IRF8 Antibody |
Human | ELISA, IHC |
IRF8 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011823HA01MO | Irf8 Antibody |
Mouse, Human | ELISA, WB |
IRF8 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-EP011823MO | Recombinant Mouse Interferon regulatory factor 8 (Irf8) |
E.coli |
CSB-YP011823MO CSB-BP011823MO CSB-MP011823MO CSB-EP011823MO-B |
Recombinant Mouse Interferon regulatory factor 8 (Irf8) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IRF8 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP011823CH CSB-EP011823CH CSB-BP011823CH CSB-MP011823CH CSB-EP011823CH-B |
Recombinant Chicken Interferon regulatory factor 8 (IRF8) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |