KLK4

KLK4, also known as Kallikrein - related peptidase 4, is a member of the kallikrein - related peptidase family. It is commonly referred to as hK4 in some literature. KLK4 functions mainly by cleaving specific protein substrates. It participates in the protease - activated receptor (PAR) signaling pathway, which is involved in cell - cell communication and tissue remodeling.
Abnormal expression of KLK4 has been associated with various diseases, especially prostate cancer. High - level KLK4 expression may promote tumor cell invasion and metastasis. Currently, research on KLK4 - targeted drugs is in progress, aiming to develop inhibitors to block its enzymatic activity and potentially treat related diseases.