KREMEN2

KREMEN2, a transmembrane protein containing kringle domains, also known as KRM2 or MGC10791, is a regulator of the Wnt signaling pathway. It collaborates with DKK1/2 to facilitate the endocytosis of Wnt receptors LRP5 and LRP6, thereby inhibiting Wnt/β-catenin signaling, which is crucial for cell development and differentiation. KREMEN2's expression is notably elevated in various cancers, particularly squamous lung cancer, suggesting a significant role in oncogenesis. This makes KREMEN2 significant in biological and medical research.

Popular Product:

Recombinant Human Kremen protein 2 (KREMEN2), partial