L3T4

L3T4, also known as the CD4 molecule, is a crucial receptor on the surface of T lymphocytes that plays a pivotal role in T cell development, activation, and immune response. Structurally, L3T4 consists of an extracellular region, a transmembrane region, and an intracellular region, allowing it to specifically bind to major histocompatibility complex (MHC) class II molecules, which is crucial for T cells to recognize antigens. In terms of signaling pathways, when L3T4 binds to MHC class II molecules, it triggers the activation of a series of signaling pathways, including tyrosine kinase pathways, phospholipase C pathways, and calcium ion pathways. These activated pathways promote T cell proliferation, differentiation, and effector function. Functionally, L3T4 not only participates in T cell recognition of "self" and "non-self" but also plays a crucial role in the differentiation of T cells into helper T cells (Th cells) and regulates the intensity and direction of immune responses to maintain immune balance in the body.

Validated Data

Western Blot
Positive WB detected in Jurkat whole cell lysate
All lanes CD4 antibody at 0.8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 55 KDa
Observed band size: 55 KDa

IHC image of CSB-RA004935A0HU diluted at 1:100 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-RA004935A0HU diluted at 1:100 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

The following L3T4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

L3T4 Antibodies

L3T4 Proteins

L3T4 ELISA Kits

L3T4 Antibodies

L3T4 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA004935GA01HU	CD4 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA004935ESR2HU	CD4 Antibody	Human	ELISA, IHC
CSB-PA001453	CD4 Antibody	Human,Mouse	WB, IHC, IF, ELISA
CSB-PA070257	Phospho-CD4 (S433) Antibody	Human,Mouse	IHC, IF, ELISA
CSB-RA004935A0HU	CD4 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC

L3T4 Antibodies for H, M, R

Code	Product Name	Species Reactivity	Application
CSB-MA000228	CD4 Monoclonal Antibody	Human,Mouse,Rat	ELISA,IHC

L3T4 Proteins

L3T4 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP004935HU1 CSB-EP004935HU1 CSB-BP004935HU1 CSB-EP004935HU1-B	Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-CF004935HU	Recombinant Human T-cell surface glycoprotein CD4 (CD4)	in vitro E.coli expression system

L3T4 Proteins for Homo sapiens(Human)

Code	Product Name	Source
CSB-CF004935HU1	Recombinant Human T-cell surface glycoprotein CD4 (CD4), partial	in vitro E.coli expression system

L3T4 ELISA Kit

L3T4 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E08956h	Human cluster of differentiation 4,CD4 ELISA Kit	serum, plasma	0.156 ng/mL

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L3T4

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