LIMD1 Research Reagents

LIM domain-containing protein 1is a protein in humans that is encoded by LIMD1 gene. Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis.

The following LIMD1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

LIMD1 Proteins

LIMD1 Proteins for Rattus norvegicus (Rat)

LIMD1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

LIMD1 Proteins for Bos taurus (Bovine)

LIMD1 Proteins for Mus musculus (Mouse)

LIMD1 Proteins for Homo sapiens (Human)

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