LONP1

LONP1, also known as mitochondrial ATP-dependent protease, is a multifunctional mitochondrial protease encoded by the LONP1 gene. It plays a critical role in maintaining mitochondrial protein homeostasis by degrading misfolded or damaged proteins and is involved in the regulation of oxidative stress response, heat shock response, and mitochondrial DNA stability. LONP1's activity is closely associated with cardiac protection, tumor progression, and metabolic regulation, and its changes are related to various diseases, making it a key molecule in cell physiology and pathology research.