LRP8

The protein encoded by LRP8 is low-density lipoprotein receptor-related protein 8, commonly known as apolipoprotein E receptor 2 (ApoER2). As a member of the low-density lipoprotein receptor family, it mediates endocytosis of ligands such as apolipoprotein E-containing lipoproteins and plays critical roles in lipid metabolism and brain development by regulating receptor-mediated endocytosis and signal transduction.
LRP8 is involved in the reelin signaling pathway, which is essential for neuronal migration and synaptic plasticity. Dysregulation of LRP8 has been linked to Alzheimer’s disease, atherosclerosis, and various cancers. Emerging research focuses on developing LRP8-targeted therapeutics, including monoclonal antibodies and small-molecule modulators, for treating neurodegenerative and cardiovascular disorders.