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Mastermind-like protein 1 is a protein in humans that is encoded by MAML1 gene. Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
The following MAML1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
MAML1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA838784LA01HU | MAML1 Antibody |
Human | ELISA, IHC |
| CSB-PA838784LB01HU | MAML1 Antibody, HRP conjugated |
Human | ELISA |
| CSB-PA838784LC01HU | MAML1 Antibody, FITC conjugated |
Human | |
| CSB-PA838784LD01HU | MAML1 Antibody, Biotin conjugated |
Human | ELISA |
MAML1 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP761441MO CSB-EP761441MO CSB-BP761441MO CSB-MP761441MO CSB-EP761441MO-B |
Recombinant Mouse Mastermind-like protein 1 (Maml1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MAML1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP838784HU CSB-EP838784HU CSB-BP838784HU CSB-MP838784HU CSB-EP838784HU-B |
Recombinant Human Mastermind-like protein 1 (MAML1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
