MAML1

Mastermind-like protein 1 is a protein in humans that is encoded by MAML1 gene. Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

MAML1 Antibodies

MAML1 Antibodies for Human

MAML1 Proteins

MAML1 Proteins for Mus musculus (Mouse)

MAML1 Proteins for Homo sapiens (Human)

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