MAML1

Mastermind-like protein 1 is a protein in humans that is encoded by MAML1 gene. Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

The following MAML1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

MAML1 Antibodies

MAML1 Proteins

MAML1 Antibodies

MAML1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA838784LA01HU	MAML1 Antibody	Human	ELISA, IHC
CSB-PA838784LB01HU	MAML1 Antibody, HRP conjugated	Human	ELISA
CSB-PA838784LC01HU	MAML1 Antibody, FITC conjugated	Human
CSB-PA838784LD01HU	MAML1 Antibody, Biotin conjugated	Human	ELISA

MAML1 Proteins

MAML1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP761441MO CSB-EP761441MO CSB-BP761441MO CSB-MP761441MO CSB-EP761441MO-B	Recombinant Mouse Mastermind-like protein 1 (Maml1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MAML1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP838784HU CSB-EP838784HU CSB-BP838784HU CSB-MP838784HU CSB-EP838784HU-B	Recombinant Human Mastermind-like protein 1 (MAML1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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