The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity).
The following METTL14 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
METTL14 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA884519LA01HU | METTL14 Antibody |
Human | ELISA, WB |
CSB-PA884519LB01HU | METTL14 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA884519LC01HU | METTL14 Antibody, FITC conjugated |
Human | |
CSB-PA884519LD01HU | METTL14 Antibody, Biotin conjugated |
Human | ELISA |
METTL14 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA757538XA01DIL | mettl14 Antibody |
Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
METTL14 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP013729BO CSB-EP013729BO CSB-BP013729BO CSB-MP013729BO CSB-EP013729BO-B |
Recombinant Bovine N6-adenosine-methyltransferase non-catalytic subunit (METTL14) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
METTL14 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP667575MO CSB-EP667575MO CSB-BP667575MO CSB-MP667575MO CSB-EP667575MO-B |
Recombinant Mouse Methyltransferase-like protein 14 (Mettl14) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
METTL14 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Code | Product Name | Source |
---|---|---|
CSB-YP724142XBF CSB-EP724142XBF CSB-BP724142XBF CSB-MP724142XBF CSB-EP724142XBF-B |
Recombinant Xenopus tropicalis Methyltransferase-like protein 14 (mettl14) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
METTL14 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP726511CH CSB-EP726511CH CSB-BP726511CH CSB-MP726511CH CSB-EP726511CH-B |
Recombinant Chicken Methyltransferase-like protein 14 (METTL14) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
METTL14 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP732620PYX CSB-EP732620PYX CSB-BP732620PYX CSB-MP732620PYX CSB-EP732620PYX-B |
Recombinant Pongo abelii Methyltransferase-like protein 14 (METTL14) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
METTL14 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP747347XBE CSB-EP747347XBE CSB-BP747347XBE CSB-MP747347XBE CSB-EP747347XBE-B |
Recombinant Xenopus laevis Methyltransferase-like protein 14 (mettl14) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
METTL14 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Source |
---|---|---|
CSB-YP757538DIL CSB-EP757538DIL CSB-BP757538DIL CSB-MP757538DIL CSB-EP757538DIL-B |
Recombinant Danio rerio Methyltransferase-like protein 14 (mettl14) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
METTL14 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP884519HU CSB-EP884519HU CSB-BP884519HU CSB-MP884519HU CSB-EP884519HU-B |
Recombinant Human N6-adenosine-methyltransferase non-catalytic subunit (METTL14) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |