METTL14 Research Reagents

The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity).

The following METTL14 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

METTL14 Antibodies

METTL14 Antibodies for Homo sapiens (Human)

METTL14 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

METTL14 Proteins

METTL14 Proteins for Bos taurus (Bovine)

METTL14 Proteins for Mus musculus (Mouse)

METTL14 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

METTL14 Proteins for Gallus gallus (Chicken)

METTL14 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

METTL14 Proteins for Xenopus laevis (African clawed frog)

METTL14 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

METTL14 Proteins for Homo sapiens (Human)

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