NOTCH1

Neurogenic locus notch homolog protein 1 is a protein in humans that is encoded by NOTCH1 gene. Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation.

NOTCH1 Antibodies

NOTCH1 Antibodies for Homo sapiens (Human)

NOTCH1 Proteins

NOTCH1 Proteins for Homo sapiens (Human)

NOTCH1 Proteins for Xenopus laevis (African clawed frog)

NOTCH1 ELISA Kit

NOTCH1 ELISA Kit for Homo sapiens (Human)

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