Neurogenic locus notch homolog protein 1 is a protein in humans that is encoded by NOTCH1 gene. Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation.
NOTCH1 Antibodies for Homo sapiens (Human)
|Code||Product Name||Species Reactivity||Application|
|CSB-PA000057||Cleaved-NOTCH1 (V1754) Antibody||Human,Mouse,Rat||WB,IHC,ELISA|
|CSB-PA015949LA01HU||NOTCH1 Antibody||Human||ELISA, IHC, IF|
|CSB-PA015949LB01HU||NOTCH1 Antibody, HRP conjugated||Human||ELISA|
|CSB-PA015949LC01HU||NOTCH1 Antibody, FITC conjugated||Human||ELISA|
|CSB-PA015949LD01HU||NOTCH1 Antibody, Biotin conjugated||Human||ELISA|
NOTCH1 Proteins for Homo sapiens (Human)
|Recombinant Human Neurogenic locus notch homolog protein 1(NOTCH1) ,partial|| Yeast
NOTCH1 Proteins for Xenopus laevis (African clawed frog)
|Recombinant Xenopus laevis Neurogenic locus notch protein homolog(notch1) ,partial|| Yeast
NOTCH1 ELISA Kit for Homo sapiens (Human)
|Code||Product Name||Sample Types||Sensitivity|
|CSB-EL015949HU||Human Neurogenic locus notch homolog protein 1(NOTCH1) ELISA kit||serum, plasma, tissue homogenates||19.5 pg/mL|
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