Neurogenic locus notch homolog protein 1 is a protein in humans that is encoded by NOTCH1 gene. Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation.

NOTCH1 Antibodies

NOTCH1 Antibodies for Homo sapiens (Human)

Code Product Name Species Reactivity Application
CSB-PA015949GA01HU NOTCH1 Antibody Human,Mouse,Rat,Zebrafish ELISA,WB,IHC
CSB-PA000057 Cleaved-NOTCH1 (V1754) Antibody Human,Mouse,Rat WB,IHC,ELISA
CSB-PA084572 NOTCH1 Antibody Human,Rat ELISA,WB,IHC
CSB-PA185075 NOTCH1 Antibody Human,Rat ELISA,WB
CSB-PA015949LA01HU NOTCH1 Antibody Human ELISA, IHC, IF
CSB-PA015949LB01HU NOTCH1 Antibody, HRP conjugated Human ELISA
CSB-PA015949LC01HU NOTCH1 Antibody, FITC conjugated Human ELISA
CSB-PA015949LD01HU NOTCH1 Antibody, Biotin conjugated Human ELISA


NOTCH1 cDNA for Homo sapiens (Human)

Code Product Name Vector Accession NO.
CSB-CL015949HU NOTCH1 pUC NM_017617.3

NOTCH1 cDNA for Xenopus laevis (African clawed frog)

Code Product Name Vector Accession NO.
CSB-CL322025XBE notch1 pUC NM_001087605.1


NOTCH1 ELISA Kit for Homo sapiens (Human)

Code Product Name Sample Types Sensitivity
CSB-EL015949HU Human Neurogenic locus notch homolog protein 1(NOTCH1) ELISA kit serum, plasma, tissue homogenates 19.5 pg/mL


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