Neurogenic locus notch homolog protein 1 is a protein in humans that is encoded by NOTCH1 gene. Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation.
The following NOTCH1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NOTCH1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA015949GA01HU | NOTCH1 Antibody | Human,Mouse,Rat,Zebrafish | ELISA,WB,IHC |
CSB-PA000057 | Cleaved-NOTCH1 (V1754) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA084572 | NOTCH1 Antibody | Human,Rat | ELISA,WB,IHC |
CSB-PA185075 | NOTCH1 Antibody | Human,Rat | ELISA,WB |
CSB-PA015949LA01HU | NOTCH1 Antibody | Human | ELISA, IHC, IF |
CSB-PA015949LB01HU | NOTCH1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA015949LC01HU | NOTCH1 Antibody, FITC conjugated | Human | |
CSB-PA015949LD01HU | NOTCH1 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA599445A0HU | NOTCH1 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
NOTCH1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP015949HU CSB-BP015949HU CSB-MP015949HU CSB-EP015949HU-B |
Recombinant Human Neurogenic locus notch homolog protein 1 (NOTCH1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NOTCH1 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP322025XBE CSB-EP322025XBE CSB-BP322025XBE CSB-MP322025XBE CSB-EP322025XBE-B |
Recombinant Xenopus laevis Neurogenic locus notch protein homolog (notch1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NOTCH1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL015949HU | Human Neurogenic locus notch homolog protein 1(NOTCH1) ELISA kit | serum, plasma, tissue homogenates | 19.5 pg/mL |