OR51E2

OR51E2 encodes olfactory receptor 51E2, a G protein-coupled receptor (GPCR) in the olfactory receptor family. Also known as prostate-specific G-protein coupled receptor (PSGR), it is highly expressed in prostate tissue. Ligand binding activates Gαs-mediated signaling, triggering cyclic adenosine monophosphate (cAMP) accumulation, which may regulate cell proliferation and differentiation.
Aberrant OR51E2 expression correlates with prostate cancer—its overexpression links to tumor progression and poor prognosis, serving as a potential diagnostic biomarker. Current research focuses on targeted agents: small-molecule antagonists and radiolabeled ligands for imaging, aiming to improve early detection and therapeutic efficacy against prostate cancer.