ORC1

ORC1 encodes the Origin Recognition Complex Subunit 1, also known as ORC1L. As a core component of the ORC, it mediates the recognition of replication origins in the genome, initiating DNA replication by recruiting other replication factors. It integrates with cell cycle signaling pathways (e.g., CDK-cyclin complexes) to ensure timely G1/S transition and maintain genomic stability.
Dysregulation of ORC1 (overexpression or mutation) links to ovarian, lung, and other cancers, driven by disrupted DNA replication and genomic instability. Preclinical research explores small-molecule inhibitors targeting ORC1 or the ORC complex, aiming to block aberrant replication and suppress tumor growth, though such agents remain in early development stages.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ORC1 Antibody (CSB-PA003602)

Validated Data

Western Blot analysis of 3T3 cells using ORC1 Polyclonal Antibody

Western Blot analysis of NIH-3T3 HELA 293 cells using ORC1 Polyclonal Antibody

The following ORC1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ORC1 Antibodies

ORC1 Proteins

ORC1 Antibodies

ORC1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA003602	ORC1 Antibody	Human	WB, ELISA

ORC1 Antibodies for Drosophila melanogaster (Fruit fly)

Code	Product Name	Species Reactivity	Application
CSB-PA017231XA01DLU	Orc1 Antibody	Drosophila melanogaster (Fruit fly)	ELISA, WB (ensure identification of antigen)

ORC1 Antibodies for Oryza sativa subsp. japonica (Rice)

Code	Product Name	Species Reactivity	Application
CSB-PA248797XA01OFG	ORC1 Antibody	Oryza sativa subsp. japonica (Rice)	ELISA, WB (ensure identification of antigen)

ORC1 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA017231XA01SVG	ORC1 Antibody	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	ELISA, WB (ensure identification of antigen)

ORC1 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Code	Product Name	Species Reactivity	Application
CSB-PA017231XA01SXV	orc1 Antibody	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)	ELISA, WB (ensure identification of antigen)

ORC1 Proteins

ORC1 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

Code	Product Name	Source
CSB-YP017231KBK CSB-EP017231KBK CSB-BP017231KBK CSB-MP017231KBK CSB-EP017231KBK-B	Recombinant Kluyveromyces lactis Origin recognition complex subunit 1 (ORC1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ORC1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code	Product Name	Source
CSB-YP017231SVG CSB-EP017231SVG CSB-BP017231SVG CSB-MP017231SVG CSB-EP017231SVG-B	Recombinant Saccharomyces cerevisiae Origin recognition complex subunit 1 (ORC1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ORC1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Code	Product Name	Source
CSB-YP017231SXV CSB-EP017231SXV CSB-BP017231SXV CSB-MP017231SXV CSB-EP017231SXV-B	Recombinant Schizosaccharomyces pombe Origin recognition complex subunit 1 (orc1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ORC1 Proteins for Drosophila melanogaster (Fruit fly)

Code	Product Name	Source
CSB-YP017231DLU CSB-EP017231DLU CSB-BP017231DLU CSB-MP017231DLU CSB-EP017231DLU-B	Recombinant Drosophila melanogaster Origin recognition complex subunit 1 (Orc1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ORC1 Proteins for Candida albicans (Yeast)

Code	Product Name	Source
CSB-YP017231CZF CSB-EP017231CZF CSB-BP017231CZF CSB-MP017231CZF CSB-EP017231CZF-B	Recombinant Candida albicans Origin recognition complex subunit 1 (ORC1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ORC1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP621667HU CSB-EP621667HU CSB-BP621667HU CSB-MP621667HU CSB-EP621667HU-B	Recombinant Human Origin recognition complex subunit 1 (ORC1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP621667HU(A4)	Recombinant Human Origin recognition complex subunit 1 (ORC1)	E.coli
CSB-BP621667HU(A4)c7	Recombinant Human Origin recognition complex subunit 1 (ORC1)	Baculovirus
CSB-EP621667HU3	Recombinant Human Origin recognition complex subunit 1 (ORC1), partial	E.coli
CSB-EP621667HU3a0	Recombinant Human Origin recognition complex subunit 1 (ORC1), partial	E.coli
CSB-EP621667HU1b1	Recombinant Human Origin recognition complex subunit 1 (ORC1), partial	E.coli
CSB-EP621667HU2	Recombinant Human Origin recognition complex subunit 1 (ORC1), partial	E.coli
CSB-BP621667HU1	Recombinant Human Origin recognition complex subunit 1 (ORC1), partial	Baculovirus
CSB-BP621667HU2	Recombinant Human Origin recognition complex subunit 1 (ORC1), partial	Baculovirus
CSB-BP621667HU3	Recombinant Human Origin recognition complex subunit 1 (ORC1), partial	Baculovirus
CSB-EP621667HU(A4)c7	Recombinant Human Origin recognition complex subunit 1 (ORC1)	E.coli
CSB-BP621667HU(A4)(M)	Recombinant Human Origin recognition complex subunit 1 (ORC1)(R297E,S450Y,T593Y,R846E)	Homo sapiens (Human)

ORC1 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP691303BO CSB-EP691303BO CSB-BP691303BO CSB-MP691303BO CSB-EP691303BO-B	Recombinant Bovine Origin recognition complex subunit 1 (ORC1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ORC1 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)

Code	Product Name	Source
CSB-YP715359DIS CSB-EP715359DIS CSB-BP715359DIS CSB-MP715359DIS CSB-EP715359DIS-B	Recombinant Debaryomyces hansenii Origin recognition complex subunit 1 (ORC1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ORC1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP800370RA CSB-EP800370RA CSB-BP800370RA CSB-MP800370RA CSB-EP800370RA-B	Recombinant Rat Origin recognition complex subunit 1 (Orc1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ORC1 Proteins for Plasmodium falciparum (isolate 3D7)

Code	Product Name	Source
CSB-YP815516EWP CSB-EP815516EWP CSB-BP815516EWP CSB-MP815516EWP CSB-EP815516EWP-B	Recombinant Plasmodium falciparum Origin recognition complex subunit 1 (orc1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ORC1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

Code	Product Name	Source
CSB-YP884911DXU CSB-EP884911DXU CSB-BP884911DXU CSB-MP884911DXU CSB-EP884911DXU-B	Recombinant Cricetulus griseus Origin recognition complex subunit 1 (ORC1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ORC1 Proteins for Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)

Code	Product Name	Source
CSB-YP897395AYB CSB-EP897395AYB CSB-BP897395AYB CSB-MP897395AYB CSB-EP897395AYB-B	Recombinant Aeropyrum pernix Cell division control protein 6 homolog (cdc6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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ORC1

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