PARG

PARG, or Poly (ADP-ribose) glycohydrolase, is a key enzyme in DNA repair, encoded by the PARG gene and functioning in the mitochondrial matrix. It regulates the cell's response to DNA damage by hydrolyzing poly (ADP-ribose) chains, balancing the poly ADP-ribosylation process catalyzed by the PARP enzyme family, which is vital for maintaining genomic stability. PARG's abnormal expression or dysfunction is associated with diseases like cancer, and it is a potential target for drug development and disease treatment, particularly in synthetic lethal strategies for cancer treatment.